US-SOMO Small Angle Scattering Workshop

UltraScan Solution Modeler Small Angle Scattering Workshop

Presenters: Emre Brookes, University of Texas, USA, and Mattia Rocco, IRCCS AOU San Martino-IST, Istituto Nazionale per la Ricerca sul Cancro, Italy


The UltraScan Solution Modeler (US-SOMO) has, in addition to hydrodynamic parameter calculation from structure (as covered in the US-SOMO Hydrodynamics Workshop), native and wrapped tools for computation of simulated biological solution small angle scattering (BioSAS) data from structure, processing of BioSAS data and comparison of simulated data against experimental data. US-SOMO also contains powerful tools for the analysis of size exclusion coupled small angle X-ray scattering (SEC-SAXS) data [1]. In this three session workshop, we will begin with an introduction to BioSAS. This will begin with an overview of the basics of BioSAS and its importance to the researcher. Next, during the first session, we will introduce the attendees to the available BioSAS tools within US-SOMO. In the second session, the attendees will work through hands-on exercices using US-SOMO with a focus on the SEC-SAXS tools. In the final session, we will continue with additional example data sets and offer to look at any user supplied data.

It is suggested that attendees attend at least any prior sessions of this three session workshop, as earlier material will not be covered again. Additionally, registered attendees will receive instructions to install the software in the week prior to the workshop. We will provide support to resolve any installation issues during this time.

This workshop will be presented as three sessions on Monday from 11:30-13:30, 14:30-16:30 and 17:00-19:00.

[1] Brookes, E., Vachette, P., Rocco, M., Per├ęz, J. (2016). US-SOMO HPLC-SAXS module: dealing with capillary fouling and extraction of pure component patterns from poorly resolved SEC-SAXS data, J. Appl. Cryst. 49(5) doi:10.1107/S1600576716011201